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PUBLICATIONS

Let-7 enhances murine anti-tumor CD8 T cell responses by promoting memory and antagonizing terminal differentiation.

Wells AC, Hioki KA, Angelou CC, Lynch AC, Liang X, Ryan DJ, Thesmar I, Zhanybekova S, Zuklys S, Ullom J, Cheong A, Mager J, Hollander GA, Pobezinskaya EL, Pobezinsky LA.

Nat Commun. 2023 Sep 11;14(1):5585. doi: 10.1038/s41467-023-40959-7.

PMID: 37696797

LKB1 isoform expression modulates T cell plasticity downstream of PKCθ and IL-6.

Mohan D, Sherman HL, Mitra A, Lawlor R, Shanthalingam S, Ullom J, Pobezinskaya EL, Zhang G, Osborne BA, Pobezinsky LA, Tew GN, Minter LM.

Mol Immunol. 2023 May;157:129-141. doi: 10.1016/j.molimm.2023.03.020. Epub 2023 Apr 3.

PMID: 37018939

Chemical Exposures Affect Innate Immune Response to SARS-CoV-2.

Arowolo O, Pobezinsky L, Suvorov A.

Int J Mol Sci. 2021 Nov 19;22(22):12474. doi: 10.3390/ijms222212474.

PMID: 34830356

Granzyme B nanoreporter for early monitoring of tumor response to immunotherapy.

Nguyen A, Ramesh A, Kumar S, Nandi D, Brouillard A, Wells A, Pobezinsky L, Osborne B, Kulkarni AA.

Sci Adv. 2020 Oct 2;6(40):eabc2777. doi: 10.1126/sciadv.abc2777. Print 2020 Oct.

PMID: 33008894

Non-coding RNAs in CD8 T cell biology.

Wells AC, Pobezinskaya EL, Pobezinsky LA.

Mol Immunol. 2020 Feb 18;120:67-73. doi: 10.1016/j.molimm.2020.01.023. [Epub ahead of print] Review.

PMID:32085976

Differentiation of Pathogenic Th17 Cells Is Negatively Regulated by Let-7 MicroRNAs in a Mouse Model of Multiple Sclerosis.

Angelou CC, Wells AC, Vijayaraghavan J, Dougan CE, Lawlor R, Iverson E, Lazarevic V, Kimura MY, Peyton SR, Minter LM, Osborne BA, Pobezinskaya EL, Pobezinsky LA.

Front Immunol. 2020 Jan 17;10:3125. doi: 10.3389/fimmu.2019.03125. eCollection 2019.

PMID:32010153

Survival of Naïve T Cells Requires the Expression of Let-7 miRNAs.

Pobezinskaya EL, Wells AC, Angelou CC, Fagerberg E, Aral E, Iverson E, Kimura MY, Pobezinsky LA.

Front Immunol. 2019 May 3;10:955. doi: 10.3389/fimmu.2019.00955. eCollection 2019.

PMID:31130952

Let's fight cancer: let-7 is a tool to enhance antitumor immune responses.

Pobezinsky LA, Wells AC.

Future Oncol. 2018 May;14(12):1141-1145. doi: 10.2217/fon-2018-0037. Epub 2018 Apr 23. Review. No abstract available. 

PMID:29683340

Modulation of let-7 miRNAs controls the differentiation of effector CD8 T cells.

Wells AC, Daniels KA, Angelou CC, Fagerberg E, Burnside AS, Markstein M, Alfandari D, Welsh RM, Pobezinskaya EL, Pobezinsky LA.

Elife. 2017 Jul 24;6. pii: e26398. doi: 10.7554/eLife.26398.

PMID:28737488

Let-7 microRNAs target the lineage-specific transcription factor PLZF to regulate terminal NKT cell differentiation and effector function.

Pobezinsky LA, Etzensperger R, Jeurling S, Alag A, Kadakia T, McCaughtry TM, Kimura MY, Sharrow SO, Guinter TI, Feigenbaum L, Singer A.

Nat Immunol. 2015 May;16(5):517-24. doi: 10.1038/ni.3146. Epub 2015 Apr 6.

PMID:25848867

T cell receptor stimulation impairs IL-7 receptor signaling by inducing expression of the microRNA miR-17 to target Janus kinase 1.

Katz G, Pobezinsky LA, Jeurling S, Shinzawa M, Van Laethem F, Singer A.

Sci Signal. 2014 Aug 26;7(340):ra83. doi: 10.1126/scisignal.2005221.

PMID:25161318

Lck availability during thymic selection determines the recognition specificity of the T cell repertoire.

Van Laethem F, Tikhonova AN, Pobezinsky LA, Tai X, Kimura MY, Le Saout C, Guinter TI, Adams A, Sharrow SO, Bernhardt G, Feigenbaum L, Singer A.

Cell. 2013 Sep 12;154(6):1326-41. doi: 10.1016/j.cell.2013.08.009.

PMID:24034254

IL-7 signaling must be intermittent, not continuous, during CD8⁺ T cell homeostasis to promote cell survival instead of cell death.

Kimura MY, Pobezinsky LA, Guinter TI, Thomas J, Adams A, Park JH, Tai X, Singer A.

Nat Immunol. 2013 Feb;14(2):143-51. doi: 10.1038/ni.2494. Epub 2012 Dec 16.

PMID:23242416

Clonal deletion and the fate of autoreactive thymocytes that survive negative selection.

Pobezinsky LA, Angelov GS, Tai X, Jeurling S, Van Laethem F, Feigenbaum L, Park JH, Singer A.

Nat Immunol. 2012 Apr 29;13(6):569-78. doi: 10.1038/ni.2292.

PMID:22544394

Basis of CTLA-4 function in regulatory and conventional CD4(+) T cells.

Tai X, Van Laethem F, Pobezinsky L, Guinter T, Sharrow SO, Adams A, Granger L, Kruhlak M, Lindsten T, Thompson CB, Feigenbaum L, Singer A.

Blood. 2012 May 31;119(22):5155-63. doi: 10.1182/blood-2011-11-388918. Epub 2012 Mar 7.

PMID:22403258

αβ T cell receptors that do not undergo major histocompatibility complex-specific thymic selection possess antibody-like recognition specificities.

Tikhonova AN, Van Laethem F, Hanada K, Lu J, Pobezinsky LA, Hong C, Guinter TI, Jeurling SK, Bernhardt G, Park JH, Yang JC, Sun PD, Singer A.

Immunity. 2012 Jan 27;36(1):79-91. doi: 10.1016/j.immuni.2011.11.013. Epub 2011 Dec 29.

PMID:22209676

Deletion of CD4 and CD8 coreceptors permits generation of alphabetaT cells that recognize antigens independently of the MHC.

Van Laethem F, Sarafova SD, Park JH, Tai X, Pobezinsky L, Guinter TI, Adoro S, Adams A, Sharrow SO, Feigenbaum L, Singer A.

Immunity. 2007 Nov;27(5):735-50.

PMID:18023370

Restricted MHC-peptide repertoire predisposes to autoimmunity.

Logunova NN, Viret C, Pobezinsky LA, Miller SA, Kazansky DB, Sundberg JP, Chervonsky AV.

J Exp Med. 2005 Jul 4;202(1):73-84.

PMID:15998789

Mitochondria of the heart left ventricle in hypokinetic rats.

Agafonova EL, Pobezinsky LA, Shornikova MV, Chentsov YuS.

Membr Cell Biol. 1998;11(5):609-21.

PMID:9672879

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